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pentobarbital will lessen the level or effect of ritonavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.pentobarbital will lessen the level or result of ibuprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Insignificant/Significance Unidentified.pentobarbital will lessen the extent or outcome of buprenorphi